Zheng Cai-hong
Title:
Director of Pharmacy；Chief pharmaceutist;
Bio:
Education：
2001-2006Zhejiang UniversityPh.D.
1983-1987 Zhejiang University B.S.
Expertise:
Medication for pregnant and lactating women
Research Interests:
Drug delivery and targeting based on transporters
Research Narrative:
The main research direction is the sustained and controlled release of biological agents and gene targeting, especially the application of PLGA, chitosan and other biodegradable macromolecule materials in protein and polypeptide biological drugs. Two projects of the National Natural Science Foundation of China and two projects of the Provincial Natural Science Foundation were carried out; three national invention patents were awarded; and the third prize of Zhejiang Science and Technology was awarded for the construction and application of a composite carrier based on release control.
Publication:
1.Zheng Cai-Hong, Liang Wen-Quan and Zhang Ye-Ping. A protein delivery system: biodegradable alginate-chitosan-poly (lactic-co-glycolic acid) composite microspheres. Biochemical and Biophysical Research Copmmunications 2004; 323: 1321-1327.
2. Cai-Hong Zheng, He-Yong Yu, Jian-Qing Gao, Xiao-Yi Sun, Wen-Quan Liang. Hydrophilic biodegradable microspheres of interferon-alpha and its pharmacokinetics in mice. Journal of Biomedical Materials Research Part B, 2008, 85 (1):225-230
3. Cai-Hong Zheng, Wen-Quan Liang. A one-step modified method to reduce the burst initial release from PLGA microspheres. Drug Delivery, 2010, 17 (2):77-82
4. Xiaoling Zheng, Yongzhuo Huang, Caihong Zheng*, Siyu Dong, Wenquan Liang. Alginate-chitosan-PLGA composite microspheres enabling single-shot hepatitis B vaccination. AAPS J 2010, 12 (4):519-524.
5. Shuqing Zhou, Xiaoling Zheng, Caihong Zheng*, Fan Qu, Xuefen Cai, Juanhua Xu. A thermosensitive gel formulation of an empirical traditional chinese precription for treating cervical erosion.Acta Pharmaceutica Sinica B. 2012; 2(5):495-501.
6. Zhao Y, Zheng C*, Zhang L, Chen Y, Ye Y, Zhao M. Knockdown of STAT3 expression in SKOV3 cells by biodegradable siRNA–PLGA/CSO conjugate micelles. Colloids Surf B: Biointerfaces, 2015, Jan 28; 127C: 155-163.
7. Zhao MD, Cheng JL, Yan JJ, Chen FY, Sheng JZ, Sun DL, Chen J, Miao J, Zhang RJ, Zheng CH*, Huang HF*. Hyaluronic acid reagent functional chitosan-PEI conjugate with AQP2-siRNA suppressed endometriotic lesion formation. Int J Nanomedicine 2016,11(2):1323-1336.（4.32）
8. Yunchun Zhao, Li Zhang, Shisen Feng, Lu Hong, Haili Zheng, Lili Chen, Xiaoling Zheng, Yiqing Ye, Mengdan Zhao, Wenxi Wang,* Caihong Zheng,*. Efficient delivery of Notch 1 siRNA to SKOV3 cells by cationic cholesterol derivative-based liposomes. Int J Nanomedicine 2016:11 5485–5496.
9. Wenxi Wang, Shiseng Feng, Caihong Zheng*. A comparison between conventional liposome and drug-cyclodextrin complex in liposome system. International Journal of Pharmaceutics 2016 Nov 20; 513 (1-2):387-392.
10. Zeng QQ, Bai MR, Li C, Lu SH, Ma ZY, Zhao YC, Zhou H, Jiang HD, Sun DL*, Zheng CH*. Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine. Antimicrob Agents Chemother. 2019 63(8). e00199-19
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