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Zhang Dan


Vice president
Professor of Obstetrics and Gynecology, Zhejiang University School of Medicine
Chief Physician, the Department of Reproductive Endocrinology



11/2017-05/2018  Brigham and Women’s Hospital, Harvard Medical School  Visiting Scholar

09/2016-12/2016  University of California, Los Angeles (UCLA)        Visiting Scholar

0/92011-12/2011  Southampton University Hospital and Poole Hospital    Visiting Scholar

2007-2011    Zhejiang University School of Medicine   Doctor Degree

1999-2001    Zhejiang University School of Medicine   Master Degree.

1994-1999   Zhejiang University School of Medicine   Bachelor Degree in Clinical Medicine



Reproductive Endocrinology


Research Interests:

1. Safety and improvement of assisted reproductive technology

2. Reproductive aging and reproductive genetics


Research Narrative:

As an expert in reproductive medicine, Dr. Zhang Dan has dedicated herself to fundamental, clinical and translational study on reproductive aging and reproductive safety for over 20 years. She has published over 50 papers in SCI journals including Molecular Aspects of Medicine, Aging Cell, Human Genetics, and serves as the first/co-first/corresponding/co-corresponding author in 25 of them. She is in charge of six projects of National Natural Science Foundation of China, one sub-project of National Key Research and Development Program of China, one project of Zhejiang Provincial Natural Science Foundation for Distinguished Young Scientists, seven provincial-level projects, and serves as a key investigator in two projects of National Key Research and Development Program of China.



1. Li JY, Liu YF, Xu HY, Zhang JY, Lv PP, Liu ME, Ying YY, Qian YQ, Li K, Li C, Huang Y, Xu GF, Ding GL, Mao YC, Xu CM, Liu XM, Sheng JZ, Zhang D, Huang HF. Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis.J Mol Cell Biol. 2019 May 8. doi: 10.1093/jmcb/mjz035. [Epub ahead of print].

2.Zhang W, Chen Z, Yin Q, Zhang D, Racowsky C, Zhang Y. Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula. Genes Dev. 2019 Feb. doi:10.1101/gad.323105.118

3. Guo J, Lv N, Tang J, Zhang X, Peng LH, Du XF, Li S, Luo Q, Zhang D, Chen GD. Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study. Environ Int. 2018 Dec;121(Pt 2):1185-1192.

4.  Huang Y, Guo J, Lv N, Li S, Wu YQ, Bai RP, Shen J, Chen GD, Zhang D#. Associations of urinary polycyclic aromatic hydrocarbons with age at natural menopause in U.S. women aged 35-65, NHANES 2003-2012. Environ Pollut, 2018;243(Pt B):1878-86.

5.  Zhang D*, Liu YF*, Zhang Z*, Lv PP*, Liu Y, Li JY, Wu YQ, Zhang RJ, Huang Y, Xu GF, Qian YQ, Qian YL, Chen SC, Xu CM, Shen J, Zhu LL, Chen K, Zhu B, Ye XQ, Mao YC, Bo XS, Zhou CY, Wang TT, Chen DF, Yang WJ, Tan YJ, Song Y, Zhou DZ, Sheng JZ, Gao HJ, Zhu YM, Li MG, Wu LP, He L, Huang HF. Basonuclin 1 deficiency is a cause of primary ovarian insufficiency. Hum Mol Genet, 2018;27(21):3787-800.

6. Sun X, Guo JH, Zhang D, Chen JJ, Lin WY, Huang Y, Chen H, Huang WQ, Liu Y, Tsang LL, Yu MK, Chung YW, Jiang X, Huang H, Chan HC, Ruan YC. Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. EMBO Mol Med. 2018;10(10).

7. Huang Y, Li JY, Zhang F, Liu YF, Xu GF, Guo J, Zhang RJ, Wu YQ, Liu J, Chen K, Zhao W, Wu W, Hu YJ, Chen GD, Zhang D#. Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET. Arch Gynecol Obstet. 2018;298(5):1017-1027.

8.Li K, Li R, Ni Y, Sun PB, Liu Y, Zhang D, Huang HF. Novel distance-progesterone-combined selection approach improves human sperm quality. J Transl Med. 2018 Jul 20;16(1):203.

9. Zhao W, Liu YF, Xu P, Wu YQ, Chen K, Guo XY, Zhang F, Huang Y, Zhu LL, Zhang RJ, Zhang D#. Effects of estradiol for luteal phase support in fresh embryo transfer cycles: A retrospective cohort study. Clinical Endocrinology(Oxf). 2018 May 12. doi: 10.1111/cen.13740.

10. Chen XJ, Chen F, Lv PP, Zhang D, Ding GL, Hu XL, Feng C, Sheng JZ, Huang HF. Maternal high estradiol exposure alters CDKN1C and IGF2 expression in human placenta. Placenta. 2018; 61:72-79.

11.Liu F, Liu YF, Liu J, Huang Y, Xu GF, Cai J, Chen Y, Wu YQ, Ying YY, Zhang RJ, Zhang D#. Effect of different anesthesia on the reproductive and obstetric outcomes of heterotopic pregnancies. International Journal of Obstetric Anesthesia. 201834, 73–78. 

12. Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro RS, Chen ZJ. Transfer of Fresh versus Frozen Embryos in Ovulatory Women. N Engl J Med. 2018 Jan 11;378(2):126-136.

13. Xu GF, Zhou CL, Xiong YM, Li JY, Yu TT, Tian S, Lin XH, Liao Y, Lv Y, Zhang FH, Liu ZW, Shi YY, Shen Y, Sha J, Zhang D, Zhu YM, Sheng JZ, Huang HF. Reduced Intellectual Ability in Offspring of Ovarian Hyperstimulation Syndrome: A Cohort Study. EBioMedicine. 2017;20:263-7.

14. Xu GFLiao YLi JYLiu YFHuang YWu YQLiu JLv PPZhang RJZhang D#. Ovarian stimulation perturbs methylation status of placental imprinting genes and reduces blood pressure in the second generation offspringEuropean Journal of Obstetrics & Gynecology and Reproductive Biology2017.2.222112017):140~145.

15. Sun YX*, Zhang YX*, Zhang D*, Xu CM, Chen SC, Zhang JY, Ruan YC, Chen F, Zhang RJ, Qian YQ, Liu YF, Jin LY, Yu TT, Xu HY, Luo YQ, Liu XM, Sun F, Sheng JZ, Huang HF. XCI-escaping gene KDM5C contributes to ovarian development via downregulating miR-320a. Hum Genet. 2017, 136(2):1-13.

16. Lv PP, Tian S, Feng C, Li JY, Yu DQ, Jin L, Shen Y, Yu TT, Meng Y, Ding GL, Jin M, Chen XJ, Sheng JZ, Zhang D#, Huang HF#. Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring. Sci Rep. 2016 Nov 9;6:36805.

17. Zhu L, Zhang Y, Liu Y, Zhang R, Wu Y, Huang Y, Liu F, Li M, Sun S, Xing L, Zhu Y, Chen Y, Xu L, Zhou L, Huang H#, Zhang D#.Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study.Sci Rep. 2016 Oct 20;6:35141.

18.Zhang D*#, Xu GF*, Zhang RJ, Zhu YM, Gao HJ, Zhou C, Sheng JZ, Huang HF#. Decreased expression of aquaporin 2 is associated with impaired endometrial receptivity in controlled ovarian stimulation. ReprodFertil Dev. 2016, 28(4): 499-506.

19. Song Y, Wang ES, Xing LL, Shi S, Qu F, Zhang D, Li JY, Shu J, Meng Y, Sheng JZ, Zhou JH, Huang HF. Follicle-Stimulating Hormone Induces Postmenopausal Dyslipidemia Through Inhibiting Hepatic Cholesterol Metabolism. J Clin Endocrinol Metab. 2016; 101: 254–263.

20. Liu AX, Zhang D, Zhu YM, Gao HJ, Jiang JY, Hu XL, Lv PP, Leung PC, Huang HF. Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. CurrMol Med. 2016;16(3):299-311.


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