Chen Xi-jing
Title:
Associate Chief Physician, Reproductive Endocrinology Department
Bio:
Education Background:
7/2006-7/2010 School of Medicine, Zhejiang University
Degree: M.D
Major: Reproductive and Endocrinological Biology
9/2001-7/2006 School of Medicine, Zhejiang University
Degree: Bachelor
Major: Clinical Medicine
Expertise:
The diagnosis and treatment of female infertility, assisted reproductive technology and the invasive minimally surgery about infertility.
Research Interests:
The safety of assisted reproductive technology.
Research Narrative:
Dr. Chen focuses on the research about the safety of assisted reproductive technology (ART) and does some research work about the epigenetic mechanisms of the lower birth weight of ART offspring. The research work had been funded by Natural Science Foundation of Zhejiang province, the Fundamental Research Funds for the Central Universities and the Program for Zhejiang Leading Team of Innovation, P. R. China.
Publication:
1. Chen XJ, Chen F, Lv PP, Zhang D, Hu XL, Feng C, Sheng JZ, Huang HF. Maternal high estradiol exposure alters CDKN1C and IGF2 expression in human placenta. Placenta. 2018; 61: 72-79
2. Zhan Q, Qi X, Wang N, Le F, Mao L, Yang X, Yuan M, Lou H, Xu X, Chen X, Jin F. Altered methylations of H19, Snrpn, Mest and Peg3 are reversible by developmental reprogramming in kidney tissue of ICSI-derived mice. Sci Rep. 2017 Sep 20; 7(1): 11936
3. Lv PP, Tian S, Feng C, Li JY, Yu DQ, Jin L, Shen Y, Yu TT, Meng Y, Ding GL, Jin M, Chen XJ, Sheng JZ, Zhang D, Huang HF. Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring. Sci Rep. 2016 Nov 9;6:36805.
4. Wang TT, Ke ZH, Song Y, Chen LT, Chen XJ, Feng C, Zhang D, Zhang RJ, Wu YT, Zhang Y, Sheng JZ, Huang HF. Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women. Hum Reprod. 28(9): 2473-2481. 2013
5. Wang TT, Ke ZH, Song Y, Chen LT, Chen XJ, Feng C, Zhang D, Zhang RJ, Wu YT, Zhang Y, Sheng JZ, Huang HF. Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women. Hum Reprod. 28(9): 2473-2481. 2013
6. Wu YT, Wang TT, Chen XJ, Zhu XM, Dong MY, Sheng JZ, Xu CM, Huang HF. Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders. Reprod Biol Endocrinol. 10: 116. 2012
7. Ding GL, Chen XJ(co-first author), Luo Q, Dong MY, Wang N, Huang HF. Attenuated Oocyte Fertilization and Embryo Development Associated with Altered Growth Factor/Signal Transduction Induced by Endometriotic Peritoneal Fluid. Fertil Steril. 93(8): 2538-2544. 2010
8. Luo Q, Chen XJ, Ding GL, Dong MY, Huang HF. Downregulative effects of nitric oxide on oocyte fertilization and embryo development: possible roles of nitric oxide in the pathogenesis of endometriosis-associated infertility. Cell Physiol Biochem. 26(6):1023-1028. 2010
9. Li MG, Ding GL, Chen XJ, Lu XP, Dong LJ, Dong MY, Yang XF, Lu XE, Huang HF. Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome. J Clin Endocrinol Metab. 2007;92(12):4771-6
10. Chen Xijing, Huang Hefeng. Effects of chemical factors on embryonic development(review). Chinese Journal of Maternal and Child Health Research. 2006,17(3): 176-179 (in Chinese)
