Peter CK Leung

Bio:

Dr. Leung is a Professor, UBC Department of Obstetrics and Gynaecology and former Associate Dean, Graduate and Postdoctoral Education, Faculty of Medicine, UBC.

Dr. Leung has received a number of prestigious awards, including a Scholar Award and a Scientist Award from the Medical Research Council of Canada, a Michael Smith Foundation for Health Research Distinguished Scientist Award, and a Senior Investigator Award from the BC Children’s Hospital Research Institute. Dr. Leung has served on many Canadian and international organizations, including as President of the Canadian Fertility and Andrology Society, Director of the Society for the Study of Reproduction, Director of the Ovarian Workshops in the USA, temporary advisor to the World Health Organization, Fellow of the Canadian Academy for Health Sciences, Fellow of the Royal Society of Canada and Foreign Member of the Korean Academy of Science and Technology.

Dr. Leung’s research focuses on Hormonal Determinants of Women’s Reproductive Health, particularly on the molecular aspects of hormone action in reproduction. Dr. Leung’s publication record to date includes 400 papers, 26 abstracts, 22 book chapters and 7 monographs.

In 2008, Professor Leung was appointed as guest professor of Zhejiang University.

Publications:

1. Zhang XY, Chang HM, Zhu H, Liu RZ, Leung PCK. BMP6 increases TGF-β1 production by up-regulating furin expression in human granulosa-lutein cells. Cellular Signalling 55:109-118 (2019).
2. Chang HM, Wu HC, Sun ZG, Lian F, Leung PCK. Neurotrophins and glial cell line-derived neurotrophic factor in the ovary: physiological and pathophysiological implications. Hum Reprod Update 25(2):224-242 (2019).
3. Bai L, Chang HM, Zhu YM, Leung PCK. Bone morphogenetic protein 2 increases lysyl oxidase activity via up-regulation of snail in human granulosa-lutein cells. Cellular Signalling 53:201-211 (2019).
4. Li M, Zhao H, Zhao SG, Wei DM, Zhao YR, Huang T, Muhammad T, Yan L, Gao F, Li L, Lu G, Chan WY, Leung PCK, Dunaif A, Liu HB, Chen ZJ. The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome. The Journal of Clinical Endocrinology and Metabolism 104(4):1049-1059 (2019).
5. Chang HM, Leung PCK. Physiological roles of activins in the human ovary.Journal of Bio-X Research 1(3):111-119 (2018).
6. Yi Y, Cheng JC, Klausen C, Leung PCK. TGF-β1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2. Placenta 68:44-51 (2018).
7. Cui L, Fang L, Mao X, Chang HM, Leung PCK, Ye Y. GDNF-Induced Downregulation of miR-145-5p Enhances Human Oocyte Maturation and Cumulus Cell Viability. The Journal of Clinical Endocrinology and Metabolism 103(7):2510-2521 (2018).
8. Xu B, Zhou M, Wang J, Zhang D, Guo F, Si C, Leung PCK, Zhang A. Increased AIF-1-mediated TNF-α expression during implantation phase in IVF cycles with GnRH antagonist protocol. Human Reproduction 33(7):1270-1280 (2018).
9. Hong L, Peng S, Li Y, Fang Y, Wang Q, Klausen C, Yin C, Wang S, Leung PCK, Yang X. miR-106a Increases Granulosa Cell Viability and Is Downregulated in Women With Diminished Ovarian Reserve. The Journal of Clinical Endocrinology and Metabolism 103(6):2157-2166 (2018).
10. 10. AlKusayer GM, Pon JR, Peng B, Klausen C, Lisonkova S, Kinloch M, Yong P, Muhammad EMS, Leung PCK, Bedaiwy MA. HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis. Reproductive Sciences 25(6):950-957 (2018).
11. von Dadelszen P, Magee LA, Benton.SJ, Hu Y, Ansermino JM, Carleton B, Carter C, DouglasMJ, JanssenPA, Lee SK, Peter C.K, Li J, MacNab Y, Payne BA, Peng G, Rodger M, Skoll MA, Synnes A, Walley KR, Russell JA.Activated protein C as disease-modifying therapy in antenatal preeclampsia: An open-label, single arm safety and efficacy trial. Pregnancy Hypertension 13:121-126 (2018).
12. 12. Zhao HJ, Chang HM, Zhu H, Klausen C, Li Y, Leung PCK. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by inducing activin A production. Endocrinology 159(7):2815-2825 (2018).
13. 13. Zhang XY, Chang HM, Taylor EL, Leung PCK, Liu RZ. BMP6 down-regulates GDNF expression through SMAD1/5 and ERK1/2 signaling pathways in human granulosa-lutein cells. Endocrinology. Endocrinology 159(8):2926-2938 (2018).
14. 14. Zhao HJ, Klausen C, Li Y, Zhu H, Wang YL, Leung PCK. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling. Cell death & disease 9: 174 (2018).
15. 15. Lin TT, Chang HM, Hu XL, Leung PCK, Zhu YM. Follicular localization of growth differentiation factor 8 and its receptors in normal and polycystic ovary syndrome ovaries. Biology of reproduction 98: 683-694 (2018).
16. 16. Li H, Chang HM, Shi Z, Leung PCK. SNAIL Mediates TGF-beta1-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa Cells. Endocrinology 159: 1644-1657 (2018).
17. 17. Guo F, Si C, Zhou M, Wang J, Zhang D, Leung PCK, Xu B, Zhang A. Decreased PECAM1-mediated TGF-beta1 expression in the mid-secretory endometrium in women with recurrent implantation failure. Human reproduction 33: 832-843 (2018).
18. 18. Cheng JC, Yi Y, Chang HM, Leung PCK. TGF-beta1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation. Cellular signalling 43: 55-61 (2018).
19. 19. Bai L, Chang HM, Cheng JC, Chu G, Leung PCK, Yang G. Lithium chloride inhibits StAR and progesterone production through GSK-3beta and ERK1/2 signaling pathways in human granulosa-lutein cells. Molecular and cellular endocrinology 461: 89-99 (2018).
20. 20. Xiong S, Klausen C, Cheng JC, Leung PCK. TGFbeta1 induces endometrial cancer cell adhesion and migration by up-regulating integrin alphavbeta3 via SMAD-independent MEK-ERK1/2 signaling. Cellular signalling 34: 92-101 (2017).