Associate chief physician, Ph.D.
2007Ph.D. Tongji Medical College, Huazhong University of Science and Technology
2004Master of MedicineJiangxi Medical College
2000Bachelor of Medicine Tongji Medical University
Gynecologic oncology, Recurrent abortion
The mortality rate of ovarian cancer ranks first among female reproductive tract malignant tumors, which seriously threatens women's life and health. The molecular mechanism of cisplatin and paclitaxel resistance in ovarian cancer is still uncertain. As a visiting scholar, I have done research on high-throughput drug screening for ovarian cancer in the National Institutes of Health in the United States for nearly two years. Drug repurposing screening reveals novel targets and drug combinations can combat cisplatin-resistant ovarian cancer. We use drug repurposing screening in cisplatin-resistant ovarian cancer cell using FDA-approved libraries and MIPE libraries to search for possible drugs sensitive to cisplatin, and then use the screened drugs to reverse explore and construct the possible mechanism of platinum resistance in ovarian
Sima N, Sun W, Gorshkov K, Shen M, Huang W, Zhu W, Xie X, Zheng W, Cheng X. Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells. Transl Oncol. 2018 Aug;11(4):1053-1064.
Sima N, Li R, Huang W, Xu M, Beers J, Zou J, Titus S, Ottinger EA, Marugan JJ, Xie X, Zheng W. Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses. Orphanet J Rare Dis. 2018 Apr 10;13(1):54.
Sima N, Cheng X, Ye F, Ma D, Xie X, Lu W. The Overexpression of Scaffolding Protein NEDD9 Promotes Migration and Invasion in Cervical Cancer via Tyrosine Phosphorylated FAK and SRC. PLoS One 2013; 8(9): e74594.
Sima N, Wang W, Kong D, Deng D, Xu Q, Zhou J, Xu G, Meng L, Lu Y, Wang S, Ma D. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53. Apoptosis 2008; 13(2): 273-81.
Sima N, Wang S, Wang W, Kong D, Xu Q, Tian X, Luo A, Zhou J, Xu G, Meng L, Lu Y, Ma D. Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells. Gynecol Oncol 2007; 106(2): 299-304.