Department Introduction

Founded in 1972, the Department of Gynecologic Oncology at WHZJU serves as the center of clinic, teaching and research of gynecologic oncology in Zhejiang province, with a faculty of more than sixty. We have earned the reputation as an national leader in the diagnosis and treatment in gynecologic tumors. A stratification and individual comprehensive therapy system has been developed this year by combined operation, chemotherapy, with biological and endocrine therapy. We have established unique therapies to retain reproductive function of patients suffering from malignancies such as cervical cancer and endometrial cancer. We also achieved great success in improving the survival rate and quality of life for patients with advanced ovarian cancer and other gynecological malignancies. We are the drafting unit of the national guidelines for the diagnosis and treatment of gestational trophoblast disease. The cure rate of gestational trophoblast tumor and the rate of pregnancy after treatment have reached the international advanced level. Over the past several years, we have treated more than 800 gynecologic cancer patients involved/including 500 cases of cervical cancer, 130 cases of endometrial carcinoma, 100 cases of ovarian malignant tumors and 100 cases of gestational trophoblast disease as well as more than 1500 cases of CIN each year.

Currently, Dr. Wan Xiao-yun takes in charge of the Department of Gynecologic Oncology.

• Diagnosis and treatment of gynecologic malignancies

(including cancers of the ovary, cervix , endometrium , vulvar and vaginal as well as gestational trophoblast tumor).

Specialty:

• Preservation techniques for gynecologic malignancies

1. 1.Cervical radical hysterectomy for cervical cancer.
2. 2.Protection ofovarian function in young patients with gynecologic malignancies during chemotherapy.
3. 3.Reservation of fertility function in endometrial carcinoma.
4. 4.Individualized stratification for gestational trophoblastic tumor.

• Minimally invasive techniques for gynecologic malignancies

1. 1.Laparoscopic radical resection of cervical cancer
2. 2.Laparoscopic surgery for endometrial cancer.
3. 3.Laparoscopic ovarian staging for ovarian cancer
4. 4.Laparoscopic surgery for vulvar cancer

We are the drafting unit of the national guidelines for the diagnosis and treatment of gestational trophoblast disease. The cure rate of gestational trophoblast tumor and the rate of pregnancy after treatment havereached the international advanced level.

Post-graduate training in Gynecologic Oncology provides a broad range of experience in comprehensive women's health care, as well as in-depth concentration in the subspecialties.

Our faculty are nationally recognized expertsin all of the disciplines in the field. Our post-graduate education program is aimed at assuring thatthe graduate physiciansbe prepared to provide primary preventive care for women as well as advanced obstetrical and surgical intervention. Our goal is to prepare our students for the challenges of rapidly changing medicine in the future.

Training Base：

• National Standardized Residents Training Base
• National Minimally Invasive Training Base

Researchers in the Department of Gynecologic Oncology are dedicated to advancing all aspects of GYN/ON care.Several clinical and basic researches are in progress in recent years.

In gestational trophoblast tumor cases, we are thefirst topropose MTX single drug treatment of low-risk gestational trophoblast tumor cases in the domesticarea. Compared with the traditional treatment methods, it has not only shortenedthetreatment time and reduced the side reaction, but also greatly reducedthe economic cost. Wealso compared some new chemotherapy regimens with the traditional EMA-CO chemotherapy for high-risk gestational trophoblast tumor cases.

In ovarian cancer, we have formed our own unique process in the diagnosis and treatment of ovarian cancer including the large dose chemotherapy, two exploratory surgery, neoadjuvant chemotherapy, interval surgery, as well as hospice care, etc. To maximallyimprove the surgical resection rate and survival rate of advanced ovarian cancer, we set up the advanced ovarian cancer multidisciplinary team in early 2016. Our basic research on the defects and mechanisms of peritoneal local immune function in epithelial ovarian cancer has laid a theoretical and experimental basis for the treatment of ovarian cancer.

In cervical cancer, we have carried out a series of clinic study in cervical cancer such as cervical cancer screening, fertility preserving surgery in early cervical cancer, and neoadjuvant chemotherapy in patients with locally advanced cervical cancer. Since the successful operationofthe first retained reproductive function radical transabdominal cervical radical in young cervical cancer patients in 2003, a number of early stage young cervical cancer patients have been pregnantand gottheir healthy babies. Furthermore, the safety of this reproductive function retained operation has also been proved these years after a long time follow-up. Recently, this kind of radical trachelectomy hasalso successfully carried out by laparoscope. We also adopt stratified and individual treatment for cervical invasive cancer. In the treatment, the new adjuvant chemotherapy and ovarian transposition were carried out for some high risk factors, which can prolong the survival rate and improve the quality of life. The basic research of cervical cancer is mainly focused on the mechanism of HPV E6/E7 in cervical neoplasm.

In endometrial cancer,the basic and clinical research is mainly focused on the molecular biological mechanism of endometrial cancer. With the extensive application of minimally invasive techniques, most of operations are done by laparoscope including radical hysterectomy and retroperitoneal lymph node dissection etc...

Our research centers conduct both basic science and clinical research to explore a wide range of GYN/ON conditions. Physicians and scientists work together to investigate risks, test treatment strategies, and analyze outcomes associated with these conditions to optimize diagnosis and treatment for our patients.

Center for Cervical Cancer Screening Research

Center for Gestational Trophoblast Tumor

Center for Uterine Neplasm

Clinic area：Six floor, Outpatient Building No.1

Ward：Fourteen - Fifteen floor, Inpatient Building No.2

Phone: 87061501-2142