Department Introduction

1.Department Scale

Anesthesiology Department of Women’s Hospital, School of Medicine, Zhejiang University, is one of the main clinical departments in the hospital with more than sixty faculty members.

Anesthesiology Department is committed to providingclinical care，medical education and scientific research of anesthesiology.It is the labor analgesia technical guidance center in Zhejiang province, and also the training base of obstetric anesthesiaNational/Provincial Recognition& Rank 

In the field of obstetrics and gynecology, Anesthesiology Department ranks the fifth nationally, and the first provincially.

The Department of anesthesiology has earned its reputation by:

·Furthering the discipline and sharing our research discoveries worldwide to improve clinical outcomes

·Expanding knowledge of obstetrics and gynecology anesthesiology through basic and clinical research, educating patients and training young clinicians and scientists

·Providing standard service of painless labor to all women and participating in the No Pain Labor N' Delivery and promoting the labor analgesia across the country

The department of anesthesiology has established a standard diagnosis and treatment scheme for perioperative anesthesiology and analgesia management in patients undergoing obstetric and gynecological surgery. In particular, wehaveaccumulated rich clinical experience in critical obstetrics, such as dangerous placenta previa, placental abruption, placental implantation, hemorrhagic shock, disseminated vascular coagulopathy (DIC), amniotic fluid embolization, etc.

Our comprehensive anesthesiology and analgesia services include:

·Obstetrics anesthesia provides extensive expertise in high-risk pregnancies such as pre-eclampsia and placenta problems, severe cholestasis, hemorrhagic shock, disseminated vascular coagulopathy (DIC), amniotic fluid embolization, pregnancy associated with serious heart or lung conditions, etc.

·Gynecologic anesthesia is dedicated to providing safe and comfortable anesthesia for special intrauterine fetal operation, non-obstetric operation during pregnancy and operation for elderly women.

• Painless labor provides full-time intraspinal labor analgesia and a labor epidural pump during delivery, with special rich experience for scar uterine labor analgesia in the latent period.

·Various visualization techniques provides ultrasound-guide deep vein and artery puncture, ultrasound-guide nerve block (transverse abdominal muscle block, sacral canal block) and spinal canal localization.

The department of anesthesiology has some signature technologies including:

·Specializes in high-risk pregnancies, special intrauterine fetal operation, non-obstetric operation during pregnancy.

·Obstetric autogenous blood transfusion.

·Common iliac artery embolization

·Labor analgesia 24 hours per day.

·Ultrasound-guide visualization techniques.

·Painless abortion and painless oocyte retrieval.

1.Program

2.The Number of Students &Trainee

The department of anesthesiology also takes on the tasks of training and academic exchanges of obstetric and gynecology anesthesia in Zhejiang province and even the whole country. The continuing education program of the standards and advances of obstetrics and gynecology anesthesia (childbirth analgesia) as well as the short course of obstetric autotransfusion are carried out every year and attract more than 200 anesthesiologists from the whole province toparticipate in the programs.

Training Base：

• National Standardized Residents Training Base
• Master's degree and doctor's degree programs in anesthesiology of Zhejiang university
• The training base of obstetric anesthesia and capacity treatment of the Anesthesiology Branch of Chinese Medical Association and the Anesthesiologists Branch of Chinese Medical Doctor Association

1.Research Direction

·Role of Metabotropic Glutamata Receptor 1 and 5 and Transient Receptor Potential Vaniloid 1 in the visceral pain induced by uterine cervical distension

·Effect of female sex hormones on the response to the visceral pain induced by uterine cervical distension and the underlying mechanism

·Measurement of the balance of nociception-anti-nociception undergeneral anesthesia based on specific parameters derived fromplethysmographic pulse wave

·Related research on autologous blood in obstetrics

·The role of TRPM2 in sepsis and other inflammatory diseases and Related mechanism research

·Exploration of the optimal dose of vasoactive drugs in low blood pressure in patients with severe preeclampsia undergoing cesarean section

·Exploration of the optimal dose of oxytocin in low blood pressure in patients with severe preeclampsia undergoing cesarean section

·Autophagy is involved in sevoflurane-induced developmental neurotoxicity in developing rat brain.

·Role of autophagy in sevoflurane-induced developmental neurotoxicity in rat hippocampal cells.

·Neural mechanisms of attention deficit hyperactivity disorder after exposure to general anaesthetic agents in the developing brain

The department of anesthesiology has seven National Natural Science Foundation scientific research projects and more than 30 other provincial and ministerial and departmental scientific research projects. It has more than 50 papers published in authorized academic periodicals both in and abroad, 30 of which are included in SCI. Moreover, it has published high-impact articles in the core journals of anesthesiology such as Anesthesiology, British Journal of Anaesthesia, Anaesthesia, International Journal of Obstetrics Anesthesia, Innate Immunologyas the first author or the corresponding author.

A 25-year-old parturient, who was at 37 weeks gestation , was diagnosed with central core disease(CCD) with a high probability of malignant hyperthermia susceptibility（MHS）by genomic testing and planned to undergo elective cesarean surgery. She was of short stature with 152 cm high and 46.5kg weight. She showed a floppy syndrome as an infant. Subsequently, her motor skills were significantly delayed, she rolled from supine to prone at 16 months and sat independently at 20 months and could not walk until 6 years. She had a waddling gait with the left leg shorter than the right leg. Physical examination showed a severe spinal deformity associated with marked scoliosis and slight lumbar lordosis. We chose a regional anesthesia for her and avoided some trigger-MH drugs such as volatile anesthetics and suxamethonium. Her scoliosis made epidural puncture difficult, sowe delineated the anatomy of the spine with an ultrasound scan preoperatively. The blocking procedure of epidural anesthesia was performed in the left lateral position of the patient and the insertion of the needle to the epidural space was ensured by the loss of resistance by air and normal saline. Then the catheter was gently entered in the epidural space and a test dose with 3ml 2% lidocaine ruled out intrathecal or intravascular catheter placement. The patient lied down and 13ml of 1.5% lidocaine was added through the catheter. The surgery started when the plane of pain sensation loss up to T6 bilaterally. The surgery lasted 45 mins with 300ml blood loss and 100ml urine volume.Then a healthy baby girl 2930g weight was delivered. Her Apgar scores were 10,10and10 at 1,5 and 10 min after delivery. The patient was given 1.5mg of morphine through the epidural catheter in order to alleviate the pain of postoperation at the end of the surgery.

Location: 5^th floor, Building 1, Outpatient Operating Room;

4^th floor, Building 2, Gynecological Operating Room;

4^th floor, Building 3, Operating Room;

3^th floor, Building 3, Maternity Operating Room;

2^th floor, Building 1, Anesthesia and Pain Clinic

Tel :(0571) 89992426