Reproductive Endocrinology Team of WHZJU Attends IFFS 2025
The IFFS World Congress 2025 (IFFS2025) was held from Saturday April 26th to Tuesday 29th at Tokyo International Forum in Tokyo, Japan. Reproductive medicine specialists, gynecologists, embryologists, scholars and others from all over the world were invited to attend this magnificent conference. The theme of this conference was “Diversity, Sustainability and Resilience in Reproductive Medicine”.
Dr. Xiaoyu Tu gave an oral presentation titled “The effect of metabolic disorders on reproduction focus on local metabolomics changes of ovary and exploratory study of NR therapy”. It is well-known that metabolic disorder, especially obesity have a significant impact on fertility and reproductive health. In this study, we use Y123F mice as the animal model because they have metabolic disorders and infertility. A total of 12 ovary samples were collected from Y123F mice (n=6) and WT mice (n=6). Broadly targeted metabolomics analysis was performed using liquid chromatography tandem mass spectrometry LC-MS/MS method. According to metabolomic difference results between the two groups, we chose nicotinamide riboside（NR）supplement as treatment. The mice were divided into WT group, Y123F group, WT+NR group, and Y123F+NR group. After treatment, oocytes were collected from these mice. Mitochondrial membrane potential, reactive oxygen species (ROS) content, mitochondrial mtDNA copy number of oocytes were compared among each groups. Finally, we found that metabolic disorders in Y123F mice lead to significant changes in local metabolites of ovaries, further affecting the quality of oocytes. NR treatment can improve oocyte quality by enhancing mitochondrial function, which can be a potential treatment for metabolic disorders that damage fertility.
International professionals and academics have consistently praised our reproductive endocrinology department's research accomplishments and expertise. The experts all over the world, during the conference, expressed their novel studies and theories. New achievements and outstanding techniques were fully explored in IFFS meeting, which broadened our horizons, motivated our academic inspiration and improved our clinical practices skills.
IFFS was founded in 1951 and is held every three years. It is one of the most authoritative and influential academic organizations in the field of reproductive medicine worldwide. It is an international academic organization dedicated to promoting global reproductive health, infertility treatment, and the development of assisted reproductive technology (ART), and a global academic event in the field of obstetrics and gynecology. Members of IFFS include reproductive medicine experts and researchers from over 100 countries and regions around the world. The IFFS Conference aims to provide a high-level academic exchange platform for experts in the field of reproductive medicine worldwide, sharing the latest research progress, discussing cutting-edge technologies, formulating consensus on diagnosis and treatment, and promoting international cooperation and innovation in the field of reproductive medicine.
