The gynecology team of the Women's Hospital，School of Medicine，Zhejiang University participated in The 16th World Congress on Endometriosis 2025
The 16th World Congress on Endometriosis 2025 was held in Sydney, Australia from May 21 to 24, 2025. 1100 gynecologists from over 60 countries around the world gathered for this truly global conference, which was to promote understanding of the treatment, care, and impact of endometriosis on the lives of countless women. The content of this conference was very informative, focusing on the clinical treatment and basic research of endometriosis, providing more evidence-based medicine for the disease. The hot topics pointed to the further exploration of non-invasive early diagnosis and detection technology, pathogenesis, and targeted therapy for endometriosis, as well as precise surgical diagnosis and long-term management.
Numerous Chinese gynecologists and researchers attended the conference and delivered exciting lectures at different venues. Professor Xinmei Zhang from Women's Hospital，School of Medicine，Zhejiang University delivered a keynote speech titled "Mast cell-mediated pain sensitization in estrogen dependent endometriosis" at the China-Australia session of the conference. Professor Zhang pointed out that the pain of endometriosis seriously affects women's health, with 70-80% of patients presenting with various pain symptoms, including dysmenorrhea, dyspareunia, defecation pain, and chronic pelvic pain. Mechanical pain, inflammatory pain, and peripheral/central nervous system sensitization mechanisms can all lead to persistent worsening of pain. Estrogen activates the degranulation of mast cells through the membrane receptor GPR30, stimulating nerve growth and the flow of Ga2+ in the dorsal root ganglion. Knocking out GPR30 blocks the aforementioned pathway; Estrogen can also stimulate the secretion of various cell mediators and chemical factors in mast cells, leading to hyperalgesia. Director Ping Xu also participated in the conference by poster presentation, sharing research on the correlation between pregnancy outcomes and the location of lesions and placenta in patients with adenomyosis. Finally, the gynecological experts from the China-Australia session took a group photo to express their great expectations for the future research field of endometriosis!
The three-day grand event was full of exciting content and fruitful harvest. Experts from around the world presented their new research and theories on endometriosis and adenomyosis at the conference, as well as future research directions. The establishment of AI big data models, AI assisted medical technology innovation, and patient education are also the hot topics and future directions of this conference. The WCE conference has successfully concluded in Sydney, and we believe it will also light up the future of 200 million women with endometriosis worldwide!
